Scientist – Protein Biomarker Assay Development & Validation

Your Responsibilities Assay development and validation Design, plan and execute development and validation studies for protein-based biomarker assays, e.g., ELISA and other immunoassays, proximity extension assays (PEA) and functional assaysBuild robust, scalable and transferable assay workflows, and support assay transfer and the implementation of new technologiesWrite high-quality validation documentation in line with internal and regulatory standards (GLP/GCLP) Diagnostic quality and compliance Develop and validate assays to quality standards suitable for diagnostic use, including potential in-house IVD assays in line with applicable EU regulations (e.g., IVDR)Support clinical studies, from assay qualification to sample analysis and reportingHandle patient samples and data responsibly and in compliance with EU data protection law (GDPR) and internal policies Data analysis Analyze and interpret experimental data with Excel, GraphPad Prism and R or Python, applying sound statistics to reach clear biological conclusions that guide project decisionsUse AI tools, including large language models (LLMs), responsibly for data analysis, literature research and documentation, in line with data protection and quality requirementsWhere relevant, work with structured datasets and databases Communication and collaboration Work cross-functionally with R&D, Quality Assurance and external partnersContribute to SOPs, reports, manuscripts and publicationsPresent your results internally, to partners and at scientific conferences Your profile Required PhD in Biochemistry, Molecular Biology or a related fieldStrong background in protein-focused biochemistryHands-on laboratory experience in developing and validating protein assays, e.g., immunoassaysFamiliarity with working in GLP/GCLP environmentsConfident data analysis with Excel and GraphPad Prism, and working experience with R and/or PythonFluent English, written and spokenGerman at A2 level or higher, and willingness to improve towards B1 A plus Postdoctoral or industry experienceExperience with proximity extension assays and their readouts, qPCR and/or next-generation sequencing (NGS)Knowledge of diagnostic regulations (e.g., IVDR) and data protection requirements (GDPR)Experience with cellular models, ideally in a neurological contextExperience with, or strong interest in, the responsible use of LLMs and other AI tools in scientific workExposure to SQL or database environments How you work You plan, run and document your own studies in a structured and reliable wayYou communicate results clearly, in writing and in presentationsYou bring your own ideas, question existing approaches and want to help shape how the team works Why us? Translational research with direct relevance for patients with rare and neurodegenerative diseasesAn international, multidisciplinary team and close collaboration with pharmaceutical partnersRoom to take ownership of your projects, help build the team and keep learningSupport with German language coursesA 12-month contract with the possibility of transitioning to a permanent position About Us With employees from over 50 nations, CENTOGENE is a truly international company with offices is in Rostock, Berlin, Delhi, Boston, Valencia, Belgrade, and São Paulo. We were born to help diagnostic patients with rare disease and today we evolved to help patients of all clinical specialties to make bold progress with guided solutions for physicians, their patients and pharma partners.